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Fatemeh Seif, Mohammad Reza Bayatiani, Hadi Ansarihadipour, Ghasem Habibi,Samira  Sadelaji Exposure to extremely low-frequency magnetic fields (ELFMF) has been implicated in the induction of systemic redox imbalance, particularly through disruption of erythrocyte stability and plasma antioxidant defenses; therefore, this experimental study was designed to evaluate the protective properties of Myrtus communis extract against ELFMF-induced oxidative […]

Rahmani S, Ansarihadipour H, Bayatiani MR, Khosrowbeygi A, Babaei S, Rasmi Y. Exposure to Electromagnetic fields (EMF) has been increasingly associated with cellular redox perturbations through the generation of reactive oxygen species, particularly under conditions of extremely low-frequency electromagnetic fields (ELF-EMF), where biological systems exhibit altered susceptibility to oxidative stress. In this investigation, we evaluated […]

Naghmeh Haddadi, Mehrzad Mirzania, and Hadi Ansarihadipour Syringic acid (SA) is a phenolic acid compound with antioxidant properties, investigated as a natural antioxidant agent in acute myeloid leukemia (AML), where oxidative stress contributes to disease progression and therapeutic resistance. Our investigation employed a sex- and age-matched design including healthy donors and AML patients at diagnosis, […]

Mohamadreza Bayatiani, Hadi Ansarihadipour, Fatemeh Seif, Samira Sadelaji, Ghasem Habibi In the era of rapid technological development and increasing environmental exposure, understanding the biological consequences of physical and chemical stressors has become a major focus of biomedical research. Oxidative imbalance represents a central mechanism linking environmental challenges with cellular dysfunction, particularly through excessive reactive oxygen […]

Hadi Ansarihadipour, Fatemeh Seif, Mohamad Reza Bayatiani Exposure to ionizing radiation remains a critical biomedical concern due to its capacity to induce systemic oxidative imbalance by generating excessive reactive oxygen species, thereby disrupting redox homeostasis and impairing macromolecular integrity in circulating blood components. Within this conceptual framework, radiation-induced hemotoxicity is increasingly recognized as a multi-layered […]

Abstract Oxidative stress represents a fundamental pathological mechanism connecting metabolic dysfunction, chronic inflammation, and progressive cellular injury. Emerging evidence indicates that glucagon-like peptide-1 (GLP-1) receptor signaling extends beyond its classical incretin function in glucose regulation and acts as a critical molecular interface between metabolic control, redox homeostasis, and cellular protection [1–3]. Activation of GLP-1 pathways […]

Mechanisms, Clinical Benefits, Safety Monitoring, and Nursing Considerations Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a rapidly expanding class of incretin-based therapies originally developed for the management of type 2 diabetes mellitus (T2DM). Their clinical applications have expanded significantly due to their beneficial effects on weight management, cardiovascular risk reduction, and metabolic disease modification.¹ […]

GLP-1 receptor agonists are incretin-based therapies initially developed for type 2 diabetes mellitus and now widely used in obesity and cardiometabolic risk management. They mimic endogenous glucagon-like peptide-1 (GLP-1), a gut-derived hormone involved in glucose regulation and appetite control. 1. Mechanism of Action GLP-1 receptor agonists act through multiple physiological pathways: Enhance glucose-dependent insulin secretion […]

1. Overview of Enzymatic ROS/RNS/RSS Generation Reactive oxygen, nitrogen, and sulfur species (ROS, RNS, RSS) emerge from a highly integrated enzymatic network distributed across multiple subcellular compartments. Rather than representing stochastic byproducts of metabolism and oxidative stress, these species are generated through specialized redox circuits that function as signaling modules within cellular physiology. Each enzymatic […]

1. Reactive Species as Spatially and Temporally Controlled Signaling Entities Reactive oxygen, nitrogen, and sulfur species (ROS/RNS/RSS) are increasingly understood as tightly regulated signaling mediators embedded within compartmentalized enzymatic networks rather than stochastic byproducts of oxidative metabolism. Hydrogen peroxide (H₂O₂), in particular, exhibits a unique physicochemical profile: moderate reactivity, relative stability compared to radical species, […]