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Lipid peroxidation represents a central biochemical mechanism underlying oxidative stress, characterized by the free radical-mediated oxidation of polyunsaturated fatty acids within biological membranes, ultimately compromising membrane architecture, cellular homeostasis, and tissue function. The process is initiated when excessive reactive oxygen species (ROS), particularly the hydroxyl radical, abstract hydrogen atoms from membrane phospholipids to generate lipid […]

Administration of excessive Vitamin K1 (phylloquinone) produced a pronounced age-dependent oxidative stress response characterized by distinct alterations in plasma antioxidant capacity, lipid peroxidation, and liver injury biomarkers in adult and weanling rats. Quantification of ferric reducing ability of plasma (FRAP) demonstrated that total antioxidant capacity remained unchanged in adult animals despite escalating vitamin K1 doses […]

Maintenance of systemic redox homeostasis depends on the balance between antioxidant defense and oxidative injury, making plasma total antioxidant capacity a critical determinant of susceptibility to oxidative stress. Quantification of the ferric reducing ability of plasma (FRAP) demonstrated a significant increase in antioxidant capacity in suckling rats following administration of vitamin K1 (28, 56, or […]

Naghmeh Haddadi, Mehrzad Mirzania, and Hadi Ansarihadipour Syringic acid (SA) is a phenolic acid compound with antioxidant properties, investigated as a natural antioxidant agent in acute myeloid leukemia (AML), where oxidative stress contributes to disease progression and therapeutic resistance. Our investigation employed a sex- and age-matched design including healthy donors and AML patients at diagnosis, […]

Mohamadreza Bayatiani, Hadi Ansarihadipour, Fatemeh Seif, Samira Sadelaji, Ghasem Habibi In the era of rapid technological development and increasing environmental exposure, understanding the biological consequences of physical and chemical stressors has become a major focus of biomedical research. Oxidative imbalance represents a central mechanism linking environmental challenges with cellular dysfunction, particularly through excessive reactive oxygen […]