ِDezAzma

DNA oxidation is a fundamental consequence of oxidative stress and a major determinant of genome instability, cellular senescence, and chronic disease. Although physiological concentrations of reactive oxygen species (ROS) participate in intracellular signaling and redox regulation, excessive ROS production disrupts redox homeostasis and promotes oxidative modification of nuclear and mitochondrial DNA. Endogenous ROS generated during […]

Oxidative carbohydrate modifications represent an emerging component of oxidative stress biology and redox regulation that has received less attention compared with lipid oxidation and protein oxidation. Nevertheless, carbohydrate oxidation contributes to redox imbalance, metabolic dysfunction, inflammation, and chronic disease progression. Carbohydrate-containing molecules are essential regulators of cellular communication, extracellular matrix organization, glycoprotein function, and tissue […]