ِDezAzma

Metal-catalyzed oxidative systems represent central drivers of metal-catalyzed oxidative stress and core regulators of redox biology and disease mechanisms. In particular, iron and copper act as catalytic centers. They promote the Fenton reaction and Haber–Weiss reaction. Consequently, hydroxyl radicals are generated which are reactive oxygen species (ROS) and disrupts cellular redox homeostasis. Furthermore, oxidative injury […]

Lipid peroxidation represents a central biochemical mechanism underlying oxidative stress, characterized by the free radical-mediated oxidation of polyunsaturated fatty acids within biological membranes, ultimately compromising membrane architecture, cellular homeostasis, and tissue function. The process is initiated when excessive reactive oxygen species (ROS), particularly the hydroxyl radical, abstract hydrogen atoms from membrane phospholipids to generate lipid […]

Administration of excessive Vitamin K1 (phylloquinone) produced a pronounced age-dependent oxidative stress response characterized by distinct alterations in plasma antioxidant capacity, lipid peroxidation, and liver injury biomarkers in adult and weanling rats. Quantification of ferric reducing ability of plasma (FRAP) demonstrated that total antioxidant capacity remained unchanged in adult animals despite escalating vitamin K1 doses […]

Occupational exposure to aluminum represents a significant source of aluminum-induced oxidative stress, where disruption of redox homeostasis accelerates oxidative injury to circulating blood components and compromises systemic antioxidant defense. Evaluation of blood samples obtained from hospital operating room personnel demonstrated that aluminum-mediated metal-catalyzed oxidation profoundly altered the biochemical balance between oxidants and antioxidants. Ferric reducing […]

In diabetes mellitus, chronic hyperglycemia drives excessive formation of reactive oxygen species (ROS), establishing a sustained state of oxidative stress biomarker imbalance that contributes to erythrocyte dysfunction and progressive anemia. In advanced renal disease, the hemodialysis environment introduces additional biochemical stressors, amplifying systemic redox disruption and accelerating molecular injury within circulating blood components. Within this […]