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Lipid peroxidation represents a central biochemical mechanism underlying oxidative stress, characterized by the free radical-mediated oxidation of polyunsaturated fatty acids within biological membranes, ultimately compromising membrane architecture, cellular homeostasis, and tissue function. The process is initiated when excessive reactive oxygen species (ROS), particularly the hydroxyl radical, abstract hydrogen atoms from membrane phospholipids to generate lipid […]

Phylloquinone, the primary dietary form of Vitamin K1, is an essential fat-soluble micronutrient that serves as the indispensable cofactor for γ-glutamyl carboxylase, enabling the Vitamin K cycle and the post-translational activation of multiple Vitamin K-dependent proteins through γ-carboxylation of glutamate residues. Adequate phylloquinone metabolism ensures the biological activity of osteocalcin, matrix Gla protein (MGP), coagulation […]

Accurate evaluation of predicting the antioxidant status of human plasma by artificial neural network analysis represents an important advancement in clinical biochemistry, oxidative stress assessment, and precision medicine, particularly because simultaneous measurement of multiple oxidative and antioxidant biomarkers is labor-intensive, costly, and unsuitable for high-throughput clinical laboratories. To establish a reliable computational strategy, blood samples […]

Maintenance of systemic redox homeostasis depends on the balance between antioxidant defense and oxidative injury, making plasma total antioxidant capacity a critical determinant of susceptibility to oxidative stress. Quantification of the ferric reducing ability of plasma (FRAP) demonstrated a significant increase in antioxidant capacity in suckling rats following administration of vitamin K1 (28, 56, or […]

Fatemeh Seif, Mohammad Reza Bayatiani, Hadi Ansarihadipour, Ghasem Habibi,Samira  Sadelaji Exposure to extremely low-frequency magnetic fields (ELFMF) has been implicated in the induction of systemic redox imbalance, particularly through disruption of erythrocyte stability and plasma antioxidant defenses; therefore, this experimental study was designed to evaluate the protective properties of Myrtus communis extract against ELFMF-induced oxidative […]

Rahmani S, Ansarihadipour H, Bayatiani MR, Khosrowbeygi A, Babaei S, Rasmi Y. Exposure to Electromagnetic fields (EMF) has been increasingly associated with cellular redox perturbations through the generation of reactive oxygen species, particularly under conditions of extremely low-frequency electromagnetic fields (ELF-EMF), where biological systems exhibit altered susceptibility to oxidative stress. In this investigation, we evaluated […]

Naghmeh Haddadi, Mehrzad Mirzania, and Hadi Ansarihadipour Syringic acid (SA) is a phenolic acid compound with antioxidant properties, investigated as a natural antioxidant agent in acute myeloid leukemia (AML), where oxidative stress contributes to disease progression and therapeutic resistance. Our investigation employed a sex- and age-matched design including healthy donors and AML patients at diagnosis, […]

Mohamadreza Bayatiani, Hadi Ansarihadipour, Fatemeh Seif, Samira Sadelaji, Ghasem Habibi In the era of rapid technological development and increasing environmental exposure, understanding the biological consequences of physical and chemical stressors has become a major focus of biomedical research. Oxidative imbalance represents a central mechanism linking environmental challenges with cellular dysfunction, particularly through excessive reactive oxygen […]

Abstract Oxidative stress represents a fundamental pathological mechanism connecting metabolic dysfunction, chronic inflammation, and progressive cellular injury. Emerging evidence indicates that glucagon-like peptide-1 (GLP-1) receptor signaling extends beyond its classical incretin function in glucose regulation and acts as a critical molecular interface between metabolic control, redox homeostasis, and cellular protection [1–3]. Activation of GLP-1 pathways […]

1. Overview Oxidative stress is a central concept in modern molecular and cellular biology, describing a disruption in redox homeostasis caused by an imbalance between the generation of reactive species and the capacity of antioxidant systems. Contemporary definitions extend beyond the classical “oxidative damage” model and recognize reactive oxygen species (ROS), reactive nitrogen species (RNS), […]